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Rather than perpetuating the traditional view of dryness in the eye as the putative cause of ocular surface disease, lacrimal physiology and inflammation specialists in the US, Europe, and Singapore define dry eye as an inflammatory disease of the lacrimal functional unit resulting in tear film compositional changes, a syndrome they call LKC (lacrimal keratoconjunctivitis). The approach allows them to recognize the array of clinical conditions resulting in or from a dysfunctional tear film. Their topics include the lacrimal functional unit, the conjunctiva and tear film maintenance, the impact of systemic immune disease, sex and sex steroid influences, ocular surface epithelial stem cells, diagnostic approaches, and surgical and immunosuppressive therapies. Annotation c2004 Book News, Inc., Portland, OR (booknews.com)
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