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Liberles (molecular biology, U. of Wyoming) assembles 19 chapters drawn from the meeting, "Using Ancestral Sequence Reconstruction to Understand Protein Function," held in Kristineberg, Sweden, in March 2005. Following a historical and scientific overview of ancestral sequence reconstruction, the use of the technique to applications of drug design and substitutional mapping is discussed. Further chapters cover experimental methodology, and experimental synthesis of ancestral proteins, with specific topics addressing, for example, standard approaches for reconstruction, limitations and considerations, covarion or heterotacheous processes, the reference species tree and how different typologies can affect reconstructed sequences, converting sequences to proteins, and biological questions across different evolutionary depths. Contradictory views are presented to show the ongoing debates in the discipline. Contributors are scientists working around the world in fields such as genetics, biology, and bioinformatics. The volume is meant for graduate students and researchers in molecular biology and evolution, and evolutionary bioinformatics. Annotation c2007 Book News, Inc., Portland, OR (booknews.com)
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David A. Liberles is Assistant Professor at the Department of Molecular Biology, University of Wyoming
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